Clarissa Schmal
Deciphering osteoporosis to the bone: Solving the mystery of PTH-resistance
Clarissa Schmal will spend her 10-months at Stanford University conducting cell-based assays and animal work in Prof. Joy Wu’s laboratory to work out, why teriparatide only works for a period of 2 years before resistance develops.
Osteoporosis is a common and devastating disease, affecting 1/5 males and 1/3 women over the age of 50 years. Osteoporosis can be treated with anabolic agents such as the parathyroid hormone analogue teriparatide, that stimulates production of new bone.
Clarissa Schmal will spend her 10-months at Stanford University conducting cell-based assays and animal work in Prof. Joy Wu’s laboratory to work out, why teriparatide only works for a period of 2 years before resistance develops. Alongside Prof. Wu, Clarissa will receive supervision and guidance from Ass. Prof. Abbas Jafari at Copenhagen University who is an expert in asparaginyl endopeptidase, and enzyme that potentially plays a role in mediating breakdown of PTH.