Experiment
Luke Gamon
Mapping the Mind's Mosaic: Revealing spatial dynamics of modified proteins during neurodegeneration
Assistant Professor
University of Copenhagen
Protein dysfunction is a hallmark of neurodegenerative conditions like Parkinson鈥檚 and Alzheimer鈥檚, characterized by specific chemical modifications on proteins (post-translational modifications or PTMs) such as phosphorylation, acetylation, nitration, and ubiquitinylation. This study aims to generate detailed maps of these modified proteins in the brains of rodents and humans affected by Parkinson鈥檚 and related diseases, with the goal of identifying new biomarkers or potential drug targets by unravelling the spatial dynamics and interactions of these proteins and their PTMs.
