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G protein-coupled receptors (GPCRs) are membrane proteins that modulate cellular activity and are useful drug targets. GPR6 is a GPCR with a unique expression on cell types related to dopamine signalling, which is dysfunctional in depression. We will use a newly developed drug that binds to this receptor, CVN424, to characterise the involvement of GPR6 in stress and depressive behaviour, providing evidence for the development of new treatments and diagnostic tools.