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Mitochondria are the “metabolic engines” of our cells, converting nutritional energy into chemical energy that the body can use. These microscopic structures must constantly adapt to the ever-changing surroundings, which relies on continuous communication with the cells around them. This multi-directional communication is the research focus of Fabian Finger at the University of Copenhagen, who is setting up a research group to study the protein dynamics at the intersection between metabolism and mitochondrial composition.

Fabian Finger is combining his expertise in the cellular basis of aging and his deep understanding of metabolic processes to study protein dynamics and their role in disease. Fabian Finger says, “I’ve studied aging, with a focus on communications between different tissues, and the effect this has on protein homeostasis – the way that cells ensure that they have the right set of proteins in order to react to different demands and environments.”

Mitochondria play a role in many diseases including obesity and the age-related decline of skeletal muscle known as sarcopenia. 

Originally derived from simple micro-organisms, mitochondria are semi-independent living compartments within cells which have their own DNA, and which rely on a specific structural layout in order to carry out their functions. Their layout is defined by lipid membranes, and one of the integral components of these membranes is called cardiolipin. Some factors can trigger a reduction in the amount of cardiolipin in the mitochondria, such as metabolic disease (i.e. obesity) and aging, while other conditions such as cold-exposure or exercise are associated with an increase in cardiolipin in mitochondria. Fabian Finger and his colleagues have already shown that this dynamic is associated with disease, and his aim is to better understand the mechanisms of this phenomenon - an aim that is challenged by the dynamic influence of multiple factors. 

“Within the cell, changes to the mitochondria can lead to changes in genomic DNA expression. We will be studying the molecular mechanism of this communication, but in the context of cells that are in continuous communication with other cells embedded in similar or even other tissues,” says Fabian Finger.

Fabian Finger is excited about the opportunities a fellowship can offer him early in his independent research career, hoping that this project can contribute to uncover new treatment possibilities for millions of people living with metabolic and age-related disease.

“This fellowship allows me to understand the mechanism of communication between mitochondria and surrounding cells in more detail to fill the many gaps in our current knowledge. It will be a springboard to allow me to develop into translational and patient-focused work which might benefit those living with disease in years to come.”

Ultimately, Fabian Finger is focused on helping us to live healthier lives for longer, which is a challenge which will require a much better understanding of a complicated field. Working at the intersection between different disciplines is something that Fabian Finger sees as a strong asset